Sicilian Vampire

James Caan

Professor Bernard Issaacs

Daryl Hannah

Carmelina Trafficante

Paul Sorvino

Jimmy Scambino

Robert Loggia

Santino Trafficante Sr.

Armand Assante

Vince

Robert Davi

Big Sal - The Don

Michael Paré

Sammy

Eric Roberts

Detective Louis Marshall

Daniel Baldwin

Vito

Tony Nardi

Little Anthony (Sonny's wise guy)